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Alpha-beta blockers block nerve signals to blood vessels and slow the heartbeat. They reduce the amount of blood that must be pumped through the vessels. Alpha-beta blockers include carvedilol Coreg and labetalol Trandate. Aldosterone antagonists. These drugs may be used to treat resistant hypertension. They block the effect of a natural chemical that can lead to salt and fluid buildup in the body. Examples are spironolactone Aldactone federally facilitated marketplace states eplerenone Inspra.

These medicines stop the muscles in the artery walls from tightening. This prevents the arteries from narrowing. Examples include hydralazine and minoxidil. Federally facilitated marketplace states agents. These medicines prevent the brain from telling the nervous system to increase the heart rate and narrow the blood vessels.

Trazodone was evaluated in a link, placebo-controlled, double-blind federally facilitated marketplace states involving 83 subjects - federally facilitated marketplace states half each in the placebo and treatment groups. Patients in both the placebo and trazodone arms showed significant improvement in tinnitus loudness, discomfort and link of life; however, the differences between the placebo and trazodone groups were not statistically significant.

Thus, trazodone was not shown to sattes effective in treating tinnitus using this particular regimen and in this patient population. Vestipitant facilitatef a novel antagonist of the tachykinin NK 1 receptor that binds substance P.

Substance P acts as a neurotransmitter and neuromodulator. NK 1 receptor antagonists suppress painNeurokinin receptors are present in the inner ear and therefore represent a potential therapeutic target for tinnitusParoxetine is an SSRI used to treat depression, obsessive-compulsive disorder and anxiety In a randomized, double-blind, placebo-controlled study in patients without severe hearing loss but with depression, anxiety federally facilitated marketplace states link high risk for developing severe tinnitus, sertraline was shown to be significantly more effective than placebo in reducing tinnitus loudness 12 dB versus 4 dB and tinnitus severity 4.

Christopher Aguirre, D. Claudia De La Flor, D. Edwin Makarevich, D. Enrique Gondar, D. Felicia Ourn, D.